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Coronavirus – Some Remdesivir news crossing – FDA warns on reduced effectiveness

  
  Analysis
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US Food and Drug Administration (FDA) is warning about a newly discovered potential drug interaction related to the investigational antiviral drug remdesivir

  • Based on a recently completed non-clinical laboratory study, the FDA is revising the fact sheet for health care providers that accompanies the drug to state that co-administration of remdesivir and chloroquine phosphate or hydroxychloroquine sulfate is not recommended as it may result in reduced antiviral activity of remdesivir.
ps. I am not a pharmaceutical PhD (yet 😀 ) so just passing this along, K? Report via Market Watch
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Hopes are high for Remdesivir, which has received emergency use authorization for the treatment of hospitalized COVID-19 patients with severe disease.

Testosterone and Cortisol in Trading for Traders – Anirudh Sethi

  
Analysis, Education
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Books and films often dramatize financial-market traders as macho gamblers. Now there may be scientific evidence to back up differently as two researchers have linked testosterone levels to the success of traders in one London market while another researcher has linked testosterone and cortisol able to increase financial risk and may destabilize markets.

According to researchers stressful and competitive working environments could be increasing hormone levels and having an impact on decision-making. Experts agreed it was important to know how hormones affected traders.

Both cortisol and testosterone occur naturally in the body. The levels of cortisol do increase when we experience psychological or physical stress. This causes the blood sugar levels to rise and prepares the body for a “fight or flight” response.

The hormones testosterone and cortisol may reflect different stress triggers.

Changes in hormone levels may affect success in the financial markets.

As soon as we sense danger, our body will release adrenaline and cortisol. The adrenaline increases our blood pressure and heart rate and boosts our energy supplies, whereas cortisol has a different job.

Cortisol is also known as the stress hormone. It is a steroid hormone made in the cortex of the adrenal glands, which is released into the blood and transported all over the body. This release in our body leads to our senses being heightened and our heart rate rising. It primes us for our ‘fight or flight’ state to help us survive and get away from danger.

Cortisol is very good for the body in terms of the benefits it provides, unless you have too much of it. Our body is set to react to danger, release cortisol and adrenaline, before calming down once the danger is gone. But, if you are constantly in a state of stress, the cortisol is going to

stay being produced in your body and that’s when it can cause problems.

Nearly every cell has receptors for cortisol and this can cause different reactions taking place. When our body is preparing for fight or flight, there are functions that aren’t needed at that point in time, which means other important systems shut down. Our immune system, digestive system and reproductive system all start to shut down. These reactions are great if you’re just needing that fight or flight mode to escape a predator, but not so good if you spend all day being stressed-out about your trades.

One other issue is that you will be more susceptible to getting ill, while your immune system is

down. It goes without saying that if you’re recovering in bed, you’re not going to be trading (more…)

Gilead trial for Covid-19 meets primary endpoint

  
  Analysis
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Push stocks higher

  • Gilead Remdesivir trial for Covid-19 has met primary endpoint
  • Study to provide info on 5-day duration of therapy
  • will share added Remdesivir data from phase 3 shortly
  • Seees data from 2nd simple study at the end of May

Early data on Gilead coronavirus medicine remdesivir is very encouraging

  
  Analysis
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Antiviral medicine remdesivir is being used to treat cov1 COVID-19 patients at a Chicago hospital,

A small study only, and note: The lack of a control arm in the study could make interpreting the results more challenging, so not leaping to conclusions:
  • The University of Chicago Medicine recruited 125 people with Covid-19
  • two Phase 3 clinical trials
  • 113 had severe disease
  • All the patients been treated with daily infusions of remdesivir
  • “The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.
Pic via Wikipedia:
Antiviral medicine remdesivir is being used to treat cov1 COVID-19 patients at a Chicago hospital, 

WSJ on “promising drug combination” to treat coronavirus, and the “new data supporting this treatment”

  
  Analysis
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The Wall Street Journal on Hydroxychloroquine and azithromycin.

Physicians are using two drugs in combination
  • hydroxychloroquine and azithromycin
to treat patients with advanced Covid-19 symptoms
Kansas City area physicians … continue to treat many patients, and some have shown improvement. Major medical centers including the University of Washington and Mass General have added hydroxychloroquine to treatment options. So here’s an update, a response to some questions that have come up, and suggestions based on the latest information.
Here is the link to the article for more info – its far too detailed to go into here.

More details on the Chinese report on drugs said to treat the new coronavirus earlier

  
  Analysis
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The two drugs are arbidol and darunavir

(h/t @ Eunice Yoon, CNBC)

Both of which are said to inhibit the new coronavirus, according to researchers at the Zhejiang University. Lead scientists are recommending the drugs to be used in China’s National Health Commission’s official protocol although the commission warns that so far, there is no confirmed effective treatment still.

Just doing a little digging on the surface here, arbidol isn’t really a common drug outside of Russia and China and is not an FDA-approved treatment for influenza.
As for darunavir, it has been used to treat HIV/AIDS cases alongside other antiretrovirals such as ritonavir – currently on the NHC’s protocol list.
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